Mitochondria replacement therapy

Mitochondria replacement therapy

Postby Renata on 21 May 2019, 16:09

This piece of news is just awesome!! Willingly share:
https://biotexcom.com/a-unique-method-t ... -own-eggs/.
BioTexCom Center for Human Reproduction offers patients who are above 40 and for those, who suffer from low levels of AMH, an innovative program that makes it possible to get pregnant with their own eggs. Mitochondria replacement therapy is an innovation and a breakthrough in the field of ART and the fertility treatment. This program gives women, who underwent numerous unsuccessful IVF cycles, aged 40+, patients with low mitochondrial functional activity, an excellent chance to give birth to a child who shares a genetic relationship with her and her partner.
Mitochondrion is one of the most important components of any living cell, including the egg. In simple words, mitochondrion is the cell’s energy station. Essentially, its work consists in supplying the cell with vital energy for its normal functioning. Women that went through multiple unsuccessful IVF attempts, as well as of older reproductive age, need to restore oocyte mitochondria in order to successfully become pregnant. A woman can become pregnant only if there are functionally active mitochondria in her oocytes. Donation of mitochondria will allow thousands of hopeless women to give birth to a healthy child through IVF using mitochondrial donation. To carry out such a procedure, an egg donor with a high functional activity of mitochondria, a patient, and sperm for in vitro fertilization are required. Healthy functionally active mitochondria are taken from a donor’s oocyte and integrated with the patient’s cells. Next, fertilization with sperm and transfer of a healthy embryo into the patient’s uterus is performed. Mitochondria donation is a unique assistive reproductive technology, which is basically the implantation of a healthy and functionally active donor mitochondria into the cells of an infertile patient, that provides the patient’s cell with the necessary energy and contributes to successful pregnancy.''
Mitochondrial DNA and Human DNA are different things. It only gives that necessary energy to the oocyst and helps with developing an embryo and make it stronger. DNA is in the core of the mitochondria, which are not used for donation. Therefore, genetically, mitochondria have no effect on the embryo.
What do you, lovelies, think about it?
Has anyone already experienced this?
If yes, what were the milestones?
Costs? Requirements for the recipient? Come on, everyone, please, do share!
Renata
 
Posts: 44
Joined: 18 Nov 2015, 17:50

Re: Mitochondria replacement therapy

Postby Elizabeth on 29 Jul 2019, 22:57

This is what guys have recently shared on fb~~
''Some childless couples, especially those over the age of 40+, who are trying to become parents through in-vitro fertilization (IVF) meet with failure. Why the emphasis is put precisely on the age of forty years? Because medical statistics confirms that at the age of 40 or 45, it is much more difficult for a woman to not only get pregnant, but also to bear a healthy child.
With age, women are less likely to get pregnant
This fact does not mean that it is absolutely dangerous for a woman at the age of 40+ to become pregnant and give birth: hundreds of aged happy mothers confirm this. However, with age, a woman’s ovarian reserve decreases (the so-called stock of healthy eggs-oocytes), which reduces the chances of getting pregnant. In addition to this problem, in some aged patients who could not become pregnant using IVF, there is a low mitochondrial activity. These organelles are the most important components of any cells.
Egg cells, female reproductive cells, also cannot do without functioning mitochondria, which, in their turn, not only provide oocytes with energy, but also have their own hereditary DNA material. With a deficiency of active, functioning mitochondria in the female eggs, often even a healthy embryo placed in the woman’s uterus does not take and the pregnancy does not occur. In this case, successful IVF is possible with using donor mitochondria.
What is the basis of mitochondrial donation
Mitochondrial donation is also called the “three parents method”: the procedure is based on the transplantation of mitochondria from a female donor into an egg cell of a patient who wants to become pregnant, which is then fertilized in vitro with the sperm of a husband or partner.
That is why, when there is a deficiency in functionally active mitochondria in the female eggs, the patient is recommended to have a mitochondrial donation, a procedure that is used in the infertility treatment at the reproductive clinic. Healthy donor mitochondria are integrated with the patient’s cells, fertilized, after which a healthy embryo is placed in the woman’s uterus.
Alternative to surrogacy and the guarantee of a healthy baby
This reproductive technology is also an IVF method, enabling families to have genetically healthy children, since the mitochondrial donation uses the egg of a female donor, which does not contain defective mitochondria. The method is also recommended for women with a high probability of the development of mutations in mitochondrial DNA and subsequent severe illnesses in an unborn baby. Thus, mitochondrial donation helps barren women not only to become mothers, but also to exclude a number of genetic diseases. With the help of mitochondrial donation, a woman can bear and give birth to a child on her own without resorting to surrogacy!''
Elizabeth
 
Posts: 22
Joined: 19 Nov 2015, 16:31


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