Reasones For Failed IVF

Reasones For Failed IVF

Postby Anabel on 06 Nov 2012, 12:47

A failed in vitro fertilization, or failed IVF, can be the result of poor embryo implantation, poor ovarian response, uterine infection or other problems with the uterus. It also may be caused by trauma that occurs to the embryo during the procedure. The patient's immune system also might mistake the embryo for something bad in the body, causing a failed IVF much the same way the body might reject an organ transplant. Understanding theses causes is important in preparation for the next cycle. :arrow: :arrow:
Anabel
 
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Re: Reasones For Failed IVF

Postby Agnes on 07 Apr 2015, 14:38

I completely agree with Anabel. Moreover much depends on the day of the transfer. Some clinics transfer the embryo on the third day. The others transfer the embryo on the fifth day. The embryo transfer on the fifth day gives more opportunity to get pregnant. The medicines are also very important. The doctor has to examine the lady before giving her any pills or injections. There are a lot of different factors that doctor must take into consideration.
Agnes
 
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Re: Reasones For Failed IVF

Postby Martina on 06 Jun 2016, 14:15

Hi, just drooped in to add the following reasons for the failed cycle may be. To begin with, women face it because of OHSS. This is when drugs used for egg production stimulation could enlarge the ovaries to dangerous extents. On such circumstances the treatment is usually likely to be concealed. Another reason is that the ovaries could not respond to the fertility drugs at all.
No embryos developed because the collected eggs were not fertilized. Sometimes when collecting the eggs it turns out there are none in the follicles. The follicles could develop but still be empty inside. The last one really hits. Such a tricky human nature may be! :shock:
Martina
 
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Re: Reasones For Failed IVF

Postby Grace on 13 Apr 2017, 15:32

Hi, ladies, I just want to add that sometimes a bad thinking influences on fail or even our neglection of tips before embryo transfer (if we talking about different kinds of ivf)
As far as I know, the Lifestyle Factors play an important role in this case. For example, many fertility clinics require women to stop smoking at least three months before starting IVF treatment. Women who smoke need twice as many IVF cycles to conceive and are much more likely to miscarry than women who don’t smoke. Women who are overweight or underweight are less likely to have successful IVF treatment. The bottom line is, maintain a healthy weight. If you are overweight, losing as little as 10 percent of your body weight can make a positive difference in your ability to get pregnant. So, your way of life is important, it has an impact on your future chances to conceive.
Grace
 
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Re: Reasones For Failed IVF

Postby Laria on 20 Mar 2019, 12:17

Hey, ladies, I'm dropping in. There are 3 basic reasons why IVF fails. The first is that embryo/s transferred to the uterus were incompetent (Abnormal and thus unable to propagate a viable pregnancy). In most cases, this is due to an irregular number of chromosomes in the embryo. In the remainder. It is due to genetic or molecular embryo abnormalities.
The second reason is an underlying implantation dysfunction that prevents the embryo from properly attaching to the uterine lining. The commonest causes for this include:
A thin endometrium (measuring less than 9 mm) at the peak of estradiol stimulation. (At the time of the hCG trigger or the initiation of progesterone administration)
Surface lesions that protrude into the uterine cavity (scarring, polyps and uterine fibroids) that create a local adverse environment that prevents implantation.
Immunologic dysfunction that results in implantation failure.
The third reason relates to technical difficulty in the performance of embryo transfer, which is a rate limiting factor. It is an undeniable fact that not all RE’s are equally skilled at the performance of this important step of the IVF process. Unfortunately IVF failures are quite common before the best treatment protocol is created. :roll:
Laria
 
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Re: Reasones For Failed IVF

Postby Laria on 20 Mar 2019, 12:21

Anabel wrote:A failed in vitro fertilization, or failed IVF, can be the result of poor embryo implantation, poor ovarian response, uterine infection or other problems with the uterus. It also may be caused by trauma that occurs to the embryo during the procedure. The patient's immune system also might mistake the embryo for something bad in the body, causing a failed IVF much the same way the body might reject an organ transplant. Understanding theses causes is important in preparation for the next cycle. :arrow: :arrow:

I would have no hesitation in saying that embryo “incompetence” tops the list of reasons for IVF failure. Embryo competence declines with advancing age. This is attributable to an inevitable age-related increase in egg aneuploidy (missing or extra chromosomes in the egg). Unfortunately, there is nothing that anyone can do about this.But it is also true that the ovarian environment created in the process of controlled ovarian stimulation (COS) can profoundly influence egg development and thus ultimately the likelihood of egg/embryo aneuploidy. Accordingly, it is imperative that a very individualized and strategic approach to COS be taken.
Laria
 
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